The Cancer Stem Cell Potency of Group 10‐Azadiphosphine Metal Complexes

The cancer stem cell (CSC) potency of a series structurally analogous Group 10-azadiphosphine metal complexes is reported. comprise 10 (Ni for 1, Pd 2, or Pt 3), an azadiphosphine ligand, and two chloride ligands. exhibit micromolar towards bulk breast cells CSCs cultured in monolayer systems. cytotoxicity the comparable to better than clinically used metallopharmaceuticals, cisplatin carboplatin, gold-standard anti-breast CSC agent, salinomycin. Notably, mammosphere inhibitory effect dependent on present, increasing following order: 3<2<1. This study highlights importance within given related compounds their activity reinforces therapeutic potential coordination as anti-CSC agents.